Article
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome.
The Journal of allergy and clinical immunology - 1 Feb 2011
Lötvall Jan, Akdis Cezmi A, Bacharier Leonard B, Bjermer Leif, Casale Thomas B, Custovic Adnan, Lemanske Robert F, Wardlaw Andrew J, Wenzel Sally E, Greenberger Paul A
Abstract excerpt
It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma. Here we...
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