Alpha-1-antitrypsin and chronic bronchitis in adult Nigerians.

Abstract excerpt

Alpha-1-antitrypsin (A1AT) serum levels and phenotypes were determined in 49 Nigerians with chronic bronchitis and 100 normal controls. The A1AT phenotypes encountered were PiMM, 69% in chronic bronchitics, 98% in controls; PiMZ, 23% in chronic bronchitics, 1% in controls; PiLM, 2% in chronic bronchitics, 1% in controls. There were three patients (6%) with the homozygous-deficient phenotype PiZZ. Spirometry...

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