Article
Characteristics and significance of albumin-positive hepatocytes in analbuminemic rats.
European journal of cell biology - 1 Dec 1990
Tanaka H, Matsuhisa A, Nagamori S, Shimizu K, Niiya M, Ohno T, Nagase S
Abstract excerpt
Analbuminemic rats (NAR) are a mutant strain in which splicing of the albumin mRNA is blocked due to a seven-base-pair deletion in an intron of the albumin gene. NAR liver contains a few hepatocytes that react with anti-rat albumin antibody (Alb+ hepatocytes), and these cells increase in number during aging and on treatment with hepatocarcinogens. To characterize these Alb+ hepatocytes, we examine their albumin...
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