Article
Polymorphisms in the pituitary growth hormone gene and its receptor associated with coronary artery disease in a predisposed cohort from India.
Journal of genetics - 1 Dec 2010
Maitra Arindam, Shanker Jayashree, Dash Debabrata, Sannappa Prathima R, John Shibu, Siwach Pratibha, Rao Veena S, Sridhara H, Kakkar Vijay V
Abstract excerpt
We investigated the promoter polymorphisms of the pituitary growth hormone gene (GH1) and exon 3 deletion polymorphism (GHRd3) in its receptor gene (GHR) in 299 angiographically proven patients with coronary artery disease (CAD) and 231 asymptomatic controls enrolled in the ongoing Indian Atherosclerosis Research Study. Real time PCR based analysis of the GHR variant showed significant association of the GHRd3...
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