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Article

Extent of hematopoietic involvement by TET2 mutations in JAK2V⁶¹⁷F polycythemia vera.

Haematologica - 1 May 2011

Swierczek Sabina I, Yoon Donghoon, Bellanné-Chantelot Christine, Kim Soo Jin, Saint-Martin Cécile, Delhommeau Francois, Najman Albert, Prchal Josef T

Abstract excerpt

TET2 mutations are found in polycythemia vera and it was initially reported that there is a greater TET2 mutational burden than JAK2(V617F) in polycythemia vera stem cells and that TET2 mutations precede JAK2(V617F). We quantified the proportion of TET2, JAK2(V617F) mutations and X-chromosome allelic usage in polycythemia vera cells, BFU-Es and in vitro expanded erythroid progenitors and found clonal...

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Identifiers

PMID: 21273266
DOI: 10.3324/haematol.2010.029678
PMCID: PMC3084927

Genes

TET2
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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