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Article

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

25 Jan 2011

Abstract excerpt

Crimean Congo hemorrhagic fever virus (CCHFV) is a deadly human pathogen that evades innate immune responses by efficiently interfering with antiviral signaling pathways mediated by NF-κB, IRF3, and IFNα/β. These pathways rely on protein ubiquitination for their activation, and one outcome is the modification of proteins with the ubiquitin (Ub)-like modifier interferon-stimulated gene (ISG)15. CCHFV and related...

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PMID: 21266548
DOI: 10.1073/pnas.1015287108

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Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domainsPMID 21266548Read ↗

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