Article
No pol mutation is associated independently with the lack of immune recovery in patients infected with HIV and failing antiretroviral therapy.
Journal of medical virology - 1 Mar 2011
Gianotti Nicola, Galli Laura, Zazzi Maurizio, Ghisetti Valeria, Bonora Stefano, Micheli Valeria, Meraviglia Paola, Corsi Paola, Bruzzone Bianca, Menzo Stefano, Di Giambenedetto Simona, De Luca Andrea, Filice Gaetano, Penco Giovanni, Castagna Antonella
Abstract excerpt
An investigation was undertaken to determine whether specific pol mutations hinder long-term immune recovery regardless of virological response. In total, 826 patients with >50 HIV RNA copies/ml, who underwent genotypic resistance testing between 1 January 2000 and 31 December 2003 after >3 years of antiretroviral treatment, and were followed up for >3 years after genotypic resistance testing, were analyzed...
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