Article
Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry.
Circulation - 8 Feb 2011
Simon Tabassome, Steg Philippe Gabriel, Gilard Martine, Blanchard Didier, Bonello Laurent, Hanssen Michel, Lardoux Hervé, Coste Pierre, Lefèvre Thierry, Drouet Elodie, Mulak Geneviève, Bataille Vincent, Ferrières Jean, Verstuyft Céline, Danchin Nicolas
Abstract excerpt
BACKGROUND: Clopidogrel requires metabolic activation by cytochrome P450 2C19 (CYP2C19). Proton pump inhibitors (PPIs) that inhibit CYP2C19 are commonly coadministered with clopidogrel to reduce the risk of gastrointestinal bleeding. This analysis compares treatment outcomes for patients in the F...
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