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Article

A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.

PLoS genetics - 6 Jan 2011

Kuramoto Takashi, Kuwamura Mitsuru, Tokuda Satoko, Izawa Takeshi, Nakane Yoshifumi, Kitada Kazuhiro, Akao Masaharu, Guénet Jean-Louis, Serikawa Tadao

Abstract excerpt

The rat demyelination (dmy) mutation serves as a unique model system to investigate the maintenance of myelin, because it provokes severe myelin breakdown in the central nervous system (CNS) after normal postnatal completion of myelination. Here, we report the molecular characterization of this m...

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Identifiers

PMID: 21253565
DOI: 10.1371/journal.pgen.1001262
PMCID: PMC3017111

Genes

MRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21253565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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