Article
Interactive effects of APOE haplotype, sex, and exercise on postheparin plasma lipase activities.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2011
Seip Richard L, Zoeller Robert F, Angelopoulos Theodore J, Salonia James, Bilbie Cherie, Moyna Niall M, Miles Mary P, Visich Paul S, Pescatello Linda S, Gordon Paul M, Tsongalis Gregory J, Bausserman Linda, Thompson Paul D
Abstract excerpt
Hepatic lipase (HL) and lipoprotein lipase (LPL) activities (HLA, LPLA) modify lipoproteins and facilitate their binding to hepatic receptors. Apolipoprotein E (APOE) physically interacts with the lipases, and the three common haplotypes of the APOE gene (ε2, ε3, and ε4) yield protein isoforms (E2, E3, and E4, respectively) that are functionally different. Lipase activities themselves differ by sex and exercise...
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