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Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

12 Jan 2011

Abstract excerpt

BACKGROUND: To understand the evolutionary steps required for a virus to become virulent in a new host, a human influenza A virus (IAV), A/Hong Kong/1/68(H3N2) (HK-wt), was adapted to increased virulence in the mouse. Among eleven mutations selected in the NS1 gene, two mutations F103L and M106I had been previously detected in the highly virulent human H5N1 isolate, A/HK/156/97, suggesting a role for these...

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PMID: 21226922
DOI: 10.1186/1743-422x-8-13

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