Article
An algorithm for determining the origin of trisomy and the positions of chiasmata from SNP genotype data.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Feb 2011
Gabriel Alem S, Hassold Terry J, Thornhill Alan R, Affara Nabeel A, Handyside Alan H, Griffin Darren K
Abstract excerpt
Trisomy causes mental retardation, pregnancy loss, IVF failure, uniparental disomy and several other pathologies, and its accurate detection is thus clinically essential. Most trisomies arise at meiosis I and are associated with increasing maternal age and reduction or alteration in recombination patterns. Investigations into the relationship between trisomy and meiotic recombination have used short tandem repeat...
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