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Article

Generation of capsule-deficient Neisseria meningitidis strains by homologous recombination.

Molecular microbiology - 1 Jul 1990

Frosch M, Schultz E, Glenn-Calvo E, Meyer T F

Abstract excerpt

Capsule-deficient mutants of Neisseria meningitidis serogroup B strain B1940 were constructed by allelic replacement using the plasmids pMF120 and pMF121, which contain the flanking regions of the gene locus for the biosynthesis pathway of the group B meningococcal capsular polysaccharide. Southern blot analysis of chromosomal DNA of the capsule-deficient meningococcal strains confirmed the generation of large...

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PMID: 2122175
DOI: 10.1111/j.1365-2958.1990.tb00697.x

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