Article
Major histocompatibility complex diversity in the endangered Ethiopian wolf (Canis simensis).
Tissue antigens - 1 Feb 2011
Kennedy L J, Randall D A, Knobel D, Brown J J, Fooks A R, Argaw K, Shiferaw F, Ollier W E R, Sillero-Zubiri C, Macdonald D W, Laurenson M K
Abstract excerpt
The major histocompatibility complex (MHC) influences immune response to infection and vaccination. In most species, MHC genes are highly polymorphic, but few wild canid populations have been investigated. In Ethiopian wolves, we identified four DLA (dog leucocyte antigen)-DRB1, two DLA-DQA1 and five DQB1 alleles. Ethiopian wolves, the world's rarest canids with fewer than 500 animals worldwide, are further...
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