Article
Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis.
BMC genomics - 22 Dec 2010
Urzúa Ulises, Owens Garrison A, Zhang Gen-Mu, Cherry James M, Sharp John J, Munroe David J
Abstract excerpt
BACKGROUND: The link between reproductive life history and incidence of ovarian tumors is well known. Periods of reduced ovulations may confer protection against ovarian cancer. Using phenotypic data available for mouse, a possible association between the ovarian transcriptome, reproductive records and spontaneous ovarian tumor rates was investigated in four mouse inbred strains. NIA15k-DNA microarrays were...
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