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Article

Engineering the promiscuous racemase activity of an arylmalonate decarboxylase.

Chemistry (Weinheim an der Bergstrasse, Germany) - 10 Jan 2011

Kourist Robert, Miyauchi Yusuke, Uemura Daisuke, Miyamoto Kenji

Abstract excerpt

Variant G74C of arylmalonate decarboxylase (AMDase) from Bordatella bronchoseptica has a unique racemising activity towards profens. By protein engineering, variant G74C/V43A with a 20-fold shift towards promiscuous racemisation was obtained, based on a reduced activity in the decarboxylation rea...

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PMID: 21207573
DOI: 10.1002/chem.201001924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21207573-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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