Article
Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.
Molecular microbiology - 1 Jun 1990
Brannigan J A, Tirodimos I A, Zhang Q Y, Dowson C G, Spratt B G
Abstract excerpt
Non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae (CMRNG strains) produce altered forms of penicillin-binding protein 2 (PBP2) that have decreased affinity for penicillin. A feature of PBP2 from all CMRNG strains is the presence of an additional residue (Asp-345A...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Carrier Proteins
- Codon
- Hexosyltransferases
- Molecular Sequence Data
- Multienzyme Complexes
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Neisseria gonorrhoeae
- Penicillin Resistance
- Penicillin-Binding Proteins
- Peptidyl Transferases
- Plasmids
- Transformation, Bacterial