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Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.

Molecular microbiology - 1 Jun 1990

Brannigan J A, Tirodimos I A, Zhang Q Y, Dowson C G, Spratt B G

Abstract excerpt

Non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae (CMRNG strains) produce altered forms of penicillin-binding protein 2 (PBP2) that have decreased affinity for penicillin. A feature of PBP2 from all CMRNG strains is the presence of an additional residue (Asp-345A) that is absent from PBP2 of penicillin-sensitive strains. The role of the additional aspartic acid residue in the...

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PMID: 2120542
DOI: 10.1111/j.1365-2958.1990.tb00664.x

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