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Article

Long intergenic noncoding RNAs: new links in cancer progression.

Cancer research - 1 Jan 2011

Tsai Miao-Chih, Spitale Robert C, Chang Howard Y

Abstract excerpt

The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct...

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PMID: 21199792
DOI: 10.1158/0008-5472.CAN-10-2483
PMCID: PMC3057914

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