Article
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
Human molecular genetics - 15 Mar 2011
Okada Yukinori, Takahashi Atsushi, Ohmiya Hiroko, Kumasaka Natsuhiko, Kamatani Yoichiro, Hosono Naoya, Tsunoda Tatsuhiko, Matsuda Koichi, Tanaka Toshihiro, Kubo Michiaki, Nakamura Yusuke, Yamamoto Kazuhiko, Kamatani Naoyuki
Abstract excerpt
C-reactive protein (CRP) is a hallmark acute-phase reactant and is widely used as a blood marker for inflammation. Substantial roles of serum CRP levels in the pathogenesis of diseases have been suggested, and investigation of the mechanisms that regulate serum CRP levels would have a substantial clinical impact. Here, through genome-wide association and replication studies performed using 12 854 Japanese...
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