Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prediction of zanamivir efficiency over the possible 2009 influenza A (H1N1) mutants by multiple molecular dynamics simulations and free energy calculations.

Journal of molecular modeling - 1 Oct 2011

Pan Dabo, Sun Huijun, Bai Chongliang, Shen Yulin, Jin Nengzhi, Liu Huanxiang, Yao Xiaojun

Abstract excerpt

As one of the most important antiviral drugs against 2009 influenza A (H1N1), will zanamivir be effective for the possible drug resistant mutants? To answer this question, we combined multiple molecular dynamics simulations and molecular mechanics generalized Born surface area (MM-GBSA) calculations to study the efficiency of zanamivir over the most frequent drug-resistant strains of neuraminidase including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Bonding

Share to Influenza A Virus, H1N1 Subtype

Share to Molecular Dynamics Simulation

Share to Neuraminidase

Share to Protein Stability

Share to Zanamivir

Source

Identifiers

PMID: 21193941
DOI: 10.1007/s00894-010-0929-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prediction of zanamivir efficiency over the possible 2009 influenza A (H1N1) mutants by multiple molecular dynamics simulations and free energy calculations.PMID 21193941Read ↗

<i>In Silico</i> Identification of the Potential Drug Resistance Sites over 2009 Influenza A (H1N1) Virus NeuraminidaseSemantic proximity Read ↗

Exploring the mechanism of zanamivir resistance in a neuraminidase mutant: a molecular dynamics study.Semantic proximity Read ↗

Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K.Semantic proximity Read ↗

In Silico Studies Reveal Peramivir and Zanamivir as an Optimal Drug Treatment Even If H7N9 Avian Type Influenza Virus Acquires Further Resistance.Semantic proximity Read ↗

Theoretical studies on the susceptibility of oseltamivir against variants of 2009 A/H1N1 influenza neuraminidase.Semantic proximity Read ↗

Evaluation on the receptor-binding preference and drug resistance of H9N2 influenza virusesSemantic proximity Read ↗

Computational studies of H5N1 influenza virus resistance to oseltamivir.Semantic proximity Read ↗

Structural insight into the mechanism of neuraminidase inhibitor-resistant mutations in human-infecting H10N8 Influenza A virusSemantic proximity Read ↗

Computational study on the molecular mechanisms of drug resistance of Narlaprevir due to V36M, R155K, V36M+R155K, T54A, and A156T mutations of HCV NS3/4A protease.Semantic proximity Read ↗

In silico study on multidrug resistance conferred by I223R/H275Y double mutant neuraminidase.Semantic proximity Read ↗

Study of drug resistance of chicken influenza A virus (H5N1) from homology-modeled 3D structures of neuraminidases.Semantic proximity Read ↗

Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in IndiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.