Article
Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds.
Transgenic research - 1 Oct 2011
Henquet Maurice, Eigenhuijsen Jochem, Hesselink Thamara, Spiegel Holger, Schreuder Mariëlle, van Duijn Esther, Cordewener Jan, Depicker Ann, van der Krol Alexander, Bosch Dirk
Abstract excerpt
ER resident glycoproteins, including ectopically expressed recombinant glycoproteins, carry so-called high-mannose type N-glycans, which can be at different stages of processing. The presence of heterogeneous high-mannose type glycans on ER-retained therapeutic proteins is undesirable for specific therapeutic applications. Previously, we described an Arabidopsis alg3-2 glycosylation mutant in which aberrant...
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