Article
Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 May 2012
Tang T S, Prior S L, Li K W, Ireland H A, Bain S C, Hurel S J, Cooper J A, Humphries S E, Stephens J W
Abstract excerpt
Glutathione peroxidase-1 (GPx-1) is an endogenous anti-oxidant enzyme. The T allele of the GPx-1 rs1050450 (C > T) gene variant is associated with reduced enzyme activity. Our aim was to examine the association between this gene variant and peripheral neuropathy in two cross-sectional samples of subjects with diabetes: (i) 773 Caucasian subjects were genotyped from the UCL Diabetes and Cardiovascular disease...
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