Article
Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes.
PloS one - 30 Nov 2010
Nagai Kozo, Yamamoto Ken, Fujiwara Hiroshi, An Jun, Ochi Toshiki, Suemori Koichiro, Yasumi Takahiro, Tauchi Hisamichi, Koh Katsuyoshi, Sato Maho, Morimoto Akira, Heike Toshio, Ishii Eiichi, Yasukawa Masaki
Abstract excerpt
BACKGROUND: Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of infancy or early childhood. To clarify the incidence and subtypes of FHL in Japan, we performed genetic and functional analyses of cytotoxic T lymphocytes (CTLs) in Japanese patients with FHL. DESIGN AND METHODS: Among the Japanese children with hemophagocytic lymphohistiocytosis (HLH) registered at our laboratory, those with more...
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