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Article

Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2011

Oxnard Geoffrey R, Arcila Maria E, Sima Camelia S, Riely Gregory J, Chmielecki Juliann, Kris Mark G, Pao William, Ladanyi Marc, Miller Vincent A

Abstract excerpt

PURPOSE: Patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI) after a median of 10 to 16 months. In half of these cases, a second EGFR mutation, T790M, underlies acquired resistance. We undertook this...

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Identifiers

PMID: 21135146
DOI: 10.1158/1078-0432.CCR-10-2692
PMCID: PMC3060283

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21135146-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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