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Article

Association Between EGFR T790M Status and Progression Patterns During Initial EGFR-TKI Treatment in Patients Harboring EGFR Mutation.

Clinical lung cancer - 1 Nov 2017

Oya Yuko, Yoshida Tatsuya, Kuroda Hiroaki, Shimizu Junichi, Horio Yoshitsugu, Sakao Yukinori, Inaba Yoshitaka, Hida Toyoaki, Yatabe Yasushi

Abstract excerpt

BACKGROUND: Emergence of the T790M point mutation in exon 20 of the epidermal growth factor receptor (EGFR) is the most common mechanism of resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs). The aim of this study was to investigate the association between T790M mutation status and the progression patterns during EGFR-TKI treatment. METHODS: We reviewed 181 patients with advanced non-small-cell lung cancer...

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PMID: 28596108
DOI: 10.1016/j.cllc.2017.05.004

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EGFR

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