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Article

A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus

3 Dec 2010

Abstract excerpt

Toll-like receptors (TLRs) are the key molecular sensors used by the mammalian innate immune system to detect various types of pathogens. Tlr13 is a novel and uncharacterized member of the mammalian TLR family. Here we report the cloning and characterization of tlr13. Tlr13 is predominantly expressed in the spleen, particularly in dendritic cells and macrophages. Tlr13 appears to activate a MyD88- and...

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PMID: 21131352
DOI: 10.1074/jbc.m110.159590

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