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Article

Reverse Engineering Gene Network Identifies New Dysferlin-interacting Proteins

2 Dec 2010

Abstract excerpt

Dysferlin (DYSF) is a type II transmembrane protein implicated in surface membrane repair of muscle. Mutations in dysferlin lead to Limb Girdle Muscular Dystrophy 2B (LGMD2B), Miyoshi Myopathy (MM), and Distal Myopathy with Anterior Tibialis onset (DMAT). The DYSF protein complex is not well understood, and only a few protein-binding partners have been identified thus far. To increase the set of interacting...

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PMID: 21119217
DOI: 10.1074/jbc.m110.173559

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