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Article

IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach

25 Nov 2010

Abstract excerpt

Mutations in the IL-2-inducible T-cell kinase gene have recently been shown to cause an autosomal recessive fatal Epstein Barr virus (EBV) associated lymphoproliferation. We report 3 cases from a single family who presented with EBV-positive B-cell proliferation diagnosed as Hodgkin's lymphoma. Single nucleotide polymorphism array-based genome-wide linkage analysis revealed IL-2-inducible T-cell kinase as a...

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Identifiers

PMID: 21109689
DOI: 10.3324/haematol.2010.033910

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