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Article

Global metabolic phenotyping in an experimental laparotomy model of surgical trauma.

Journal of proteome research - 7 Jan 2011

Kinross James M, Alkhamesi Nawar, Barton Richard H, Silk David B, Yap Ivan K S, Darzi Ara W, Holmes Elaine, Nicholson Jeremy K

Abstract excerpt

Surgical trauma initiates a complex series of metabolic host responses designed to maintain homeostasis and ensure survival. (1)H NMR spectroscopy was applied to intraoperative urine and plasma samples as part of a strategy to analyze the metabolic response of Wistar rats to a laparotomy model. Spectral data were analyzed by multivariate statistical analysis. Principal component analysis (PCA) confirmed that...

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PMID: 21105667
DOI: 10.1021/pr1003278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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