Article
S-nitrosylation decreases the adsorption of H-Ras in lipid bilayer and changes intrinsic catalytic activity.
Cell biochemistry and biophysics - 1 Apr 2011
Shanshiashvili L, Narmania N, Barbakadze T, Zhuravliova E, Natsvlishvili N, Ramsden J, Mikeladze D G
Abstract excerpt
Structural, chemical, and mutational studies have shown that C-terminal cysteine residues on H-Ras could potentially be oxidized by nitrosylation. For investigating the effect of nitrosylation of Ras molecule on the adsorption of farnesylated H-Ras into lipid layer, experiments with optical waveguide lightmode spectroscopy were used. The analysis of association/dissociation kinetics to planar phospholipids under...
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