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Article

XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis.

Journal of digestive diseases - 1 Dec 2010

Wang Ping, Tang Jie Ting, Peng Yan Shen, Chen Xiao Yu, Zhang Yan Jie, Fang Jing Yuan

Abstract excerpt

OBJECTIVE: To analyze the expression and aberrant methylation of X-ray repair cross-complementing gene 1 (XRCC1) in gastric carcinogenesis, and identify the molecular mechanism of gastric carcinogenesis. METHODS: The method based on methyl binding domain protein (MBD) immuno-precipitation and promoter microarray was employed to screen the gastric cancer-related methylation-sensitive gene. An immunohistochemistry...

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Source

Identifiers

PMID: 21091896
DOI: 10.1111/j.1751-2980.2010.00459.x

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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