Article
Antibiotic resistant mutants of Escherichia coli K12 show increases in heterologous gene expression.
Plasmid - 1 Jan 2011
Ahmetagic Adnan, Pemberton John M
Abstract excerpt
Using a variety of antibiotics, it was found that nine separate isolates of spontaneous antibiotic resistant mutants of Escherichia coli K12 pPSX-vioABCDE overproduce the anti-tumour antibiotic violacein. Subsequent analysis showed that seven of these mutations occurred on the plasmid pPSX-vioABCDE. The other two overproducing strains carried spontaneous chromosomal mutations to lincomycin and kanamycin. The...
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