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Article

Inference of haplotypes from PCR-amplified samples of diploid populations.

Molecular biology and evolution - 1 Mar 1990

Clark A G

Abstract excerpt

Direct sequencing of genomic DNA from diploid individuals leads to ambiguities on sequencing gels whenever there is more than one mismatching site in the sequences of the two orthologous copies of a gene. While these ambiguities cannot be resolved from a single sample without resorting to other experimental methods (such as cloning in the traditional way), population samples may be useful for inferring...

Topics

Algorithms
Alleles
Animals
Base Sequence
DNA
Diploidy
Drosophila melanogaster
Haplotypes
Models, Genetic
Polymerase Chain Reaction
Polymorphism, Genetic
Probability

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Identifiers

PMID: 2108305
DOI: 10.1093/oxfordjournals.molbev.a040591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2108305-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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