Article
sRNAs as possible regulators of retrotransposon activity in Cryptococcus gattii VGII.
BMC genomics - 12 Apr 2017
Ferrareze Patrícia Aline Gröhs, Streit Rodrigo Silva Araujo, Dos Santos Francine Melise, Schrank Augusto, Kmetzsch Livia, Vainstein Marilene Henning, Staats Charley Christian
Abstract excerpt
BACKGROUND: The absence of Argonaute genes in the fungal pathogen Cryptococcus gattii R265 and other VGII strains indicates that yeasts of this genotype cannot have a functional RNAi pathway, an evolutionarily conserved gene silencing mechanism performed by small RNAs. The success of the R265 strain as a pathogen that caused the Pacific Northwest and Vancouver Island outbreaks may imply that RNAi machinery loss...
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