Article
Outer membrane protein A and cytotoxic necrotizing factor-1 use diverse signaling mechanisms for Escherichia coli K1 invasion of human brain microvascular endothelial cells.
Microbial pathogenesis - 1 Jul 2003
Khan Naveed Ahmed, Shin Sooan, Chung Jin Woong, Kim Kee Jun, Elliott Simon, Wang Ying, Kim Kwang Sik
Abstract excerpt
Escherichia coli K1 invasion of brain microvascular endothelial cells (BMEC) is a prerequisite for penetration into the central nervous system. We previously have shown that outer membrane protein A (OmpA) and cytotoxic necrotizing factor-1 (CNF1) contribute to E. coli K1 invasion of BMEC. In this study we constructed a double-knockout mutant by deleting ompA and cnf1. We demonstrated that the double-knockout...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.