Article
PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected].
Anticancer research - 1 Dec 2014
Kupcinskas Juozas, Wex Thomas, Link Alexander, Bartuseviciute Ruta, Dedelaite Milda, Kevalaite Gintare, Leja Marcis, Skieceviciene Jurgita, Kiudelis Gediminas, Jonaitis Laimas, Kupcinskas Limas, Malfertheiner Peter
Abstract excerpt
BACKGROUND/AIM: Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG)....