Article
Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.
Gastroenterology - 1 Feb 2011
Lochhead Paul, Frank Bernd, Hold Georgina L, Rabkin Charles S, Ng Michael T H, Vaughan Thomas L, Risch Harvey A, Gammon Marilie D, Lissowska Jolanta, Weck Melanie N, Raum Elke, Müller Heiko, Illig Thomas, Klopp Norman, Dawson Alan, McColl Kenneth E, Brenner Hermann, Chow Wong-Ho, El-Omar Emad M
Abstract excerpt
BACKGROUND & AIMS: An association between gastric cancer and the rs2294008 (C>T) polymorphism in the prostate stem cell antigen (PSCA) gene has been reported for several Asian populations. We set out to determine whether such an association exists in white individuals. METHODS: We genotyped 166 relatives of gastric cancer patients, including 43 Helicobacter pylori-infected subjects with hypochlorhydria and...
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