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Article

Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase.

Journal of the American Chemical Society - 1 Dec 2010

Hill Melissa P, Carroll Elizabeth C, Vang Mai C, Addington Trevor A, Toney Michael D, Larsen Delmar S

Abstract excerpt

The mechanisms of pyridoxal 5'-phosphate (PLP)-dependent enzymes require substrates to form covalent "external aldimine" intermediates, which absorb light strongly between 410 and 430 nm. Aspartate aminotransferase (AAT) is a prototypical PLP-dependent enzyme that catalyzes the reversible interconversion of aspartate and α-ketoglutarate with oxalacetate and glutamate. From kinetic isotope effects studies, it is...

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PMID: 21058708
DOI: 10.1021/ja107054x
PMCID: PMC3021986

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