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Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation

27 Oct 2010

Abstract excerpt

Chronic inflammation is deeply involved in induction of aberrant DNA methylation, but it is unclear whether any type of persistent inflammation can induce methylation and how induction of cell proliferation is involved. In this study, Mongolian gerbils were treated with five kinds of inflammation inducers [Helicobacter pylori with cytotoxin-associated gene A (CagA), H.pylori without CagA, Helicobacter felis, 50%...

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PMID: 20980348
DOI: 10.1093/carcin/bgq219

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