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Article

Global Histone Modification Patterns as Prognostic Markers to Classify Glioma Patients

1 Nov 2010

Abstract excerpt

BACKGROUND: An altered pattern of epigenetic modifications is central to the development and progression of various tumors. We studied epigenetic changes involving multiple modifications of histones to better predict prognosis of glioma patients. METHODS: Immunohistochemistry was done to investigate global histone modification expression of histone 3 lysine 4 dimethylation (H3K4diMe), histone 4 arginine 3...

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PMID: 20978174
DOI: 10.1158/1055-9965.epi-10-0454

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