Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go.

Obesity facts - 1 Oct 2010

Hebebrand Johannes, Volckmar Anna-Lena, Knoll Nadja, Hinney Anke

Abstract excerpt

Although heritability of human body weight is assumed to be high, only a small fraction of the variance can as yet be attributed to molecular genetic factors. Single monogenic forms of obesity have been identified. Functionally relevant coding mutations in the melanocortin-4 receptor gene occur in 1-6% of extremely obese children and adolescents and thus represent the most common major gene effect. Genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Body Weight
Share to Europe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evidence-Based Medicine

Share to Heredity

Share to Meta-Analysis as Topic

Share to Obesity

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20975295
DOI: 10.1159/000321537
PMCID: PMC6452141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go.PMID 20975295Read ↗

Genetics of Obesity: What We Have Learned Over Decades of Research.Semantic proximity Read ↗

The genetics of obesity: from discovery to biology.Semantic proximity Read ↗

The genetics of obesity: aetiology, prevention and therapy.Semantic proximity Read ↗

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity.Semantic proximity Read ↗

Genetic studies of body mass index yield new insights for obesity biology.Semantic proximity Read ↗

The expanding landscape of genetic causes of obesity.Semantic proximity Read ↗

The Genetics of Obesity.Semantic proximity Read ↗

Genetic studies of body mass index yield new insights for obesity biologySemantic proximity Read ↗

Monogenic and complex forms of obesity: insights from genetics reveal the leptin-melanocortin signaling pathway as a common player.Semantic proximity Read ↗

Obesity and thinness: insights from genetics.Semantic proximity Read ↗

[The genetics of obesity - pathogenetic, clinical and diagnostic aspects].Semantic proximity Read ↗

Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.