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Article

Infectivity Acts as<i>In Vivo</i>Selection for Maintenance of the Chlamydial Cryptic Plasmid

26 Oct 2010

Abstract excerpt

Chlamydia trachomatis contains a conserved ∼7.5-kb plasmid. Loss of the plasmid results in reduced glycogen accumulation, failure to activate TLR2, and reduced infectivity. We hypothesized that reduced infectivity functions as a means of selection for plasmid maintenance. We directly examined the biological significance of the reduced infectivity associated with plasmid deficiency by determining the relative...

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PMID: 20974819
DOI: 10.1128/iai.01105-10

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