Plasmid deficiency in urogenital isolates of<i>Chlamydia trachomatis</i>reduces infectivity and virulence in a mouse model

Abstract excerpt

We hypothesized that the plasmid of urogenital isolates of Chlamydia trachomatis would modulate infectivity and virulence in a mouse model. To test this hypothesis, we infected female mice in the respiratory or urogenital tract with graded doses of a human urogenital isolate of C. trachomatis, serovar F, possessing the cognate plasmid. For comparison, we inoculated mice with a plasmid-free serovar F isolate....

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