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Pediatric histiocytic sarcoma clonally related to precursor B‐cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4A

22 Oct 2010

Abstract excerpt

Histiocytic sarcoma (HS) is a rare malignancy of tissue histiocytes with a dismal prognosis. We report a 4-year-old male who developed HS during maintenance chemotherapy for precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Both tumors showed identical clonal immunoglobulin and T-cell receptor gene re-arrangement patterns, as well as homozygous deletion of the CDKN2A gene encoding p16(INK4A). These data...

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PMID: 20973102
DOI: 10.1002/pbc.22810

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