Article
CCRaVAT and QuTie-enabling analysis of rare variants in large-scale case control and quantitative trait association studies.
BMC bioinformatics - 21 Oct 2010
Lawrence Robert, Day-Williams Aaron G, Elliott Katherine S, Morris Andrew P, Zeggini Eleftheria
Abstract excerpt
BACKGROUND: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of trait heritability. There has been a shift in the field towards studying low frequency and rare variants, which are now widely recognised as putative complex trait determinants. Despite this increasing focus on examining the role of low...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.