Interlaboratory standardization of the sandwich enzyme-linked immunosorbent assay designed for MATS, a rapid, reproducible method for estimating the strain coverage of investigational vaccines.

doi:10.1128/CVI.00202-12

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Article

Interlaboratory standardization of the sandwich enzyme-linked immunosorbent assay designed for MATS, a rapid, reproducible method for estimating the strain coverage of investigational vaccines.

Clinical and vaccine immunology : CVI - 1 Oct 2012

Plikaytis Brian D, Stella Maria, Boccadifuoco Giuseppe, DeTora Lisa M, Agnusdei Mauro, Santini Laura, Brunelli Brunella, Orlandi Luca, Simmini Isabella, Giuliani Marzia, Ledroit Morgan, Hong Eva, Taha Muhamed-Kheir, Ellie Kim, Rajam Gowrisankar, Carlone George M, Claus Heike, Vogel Ulrich, Borrow Ray, Findlow Jamie, Gilchrist Stefanie, Stefanelli Paola, Fazio Cecilia, Carannante Anna, Oksnes Jan, Fritzsønn Elisabeth, Klem Anne-Marie, Caugant Dominique A, Abad Raquel, Vázquez Julio A, Rappuoli Rino, Pizza Mariagrazia, Donnelly John J, Medini Duccio

Abstract excerpt

The meningococcal antigen typing system (MATS) sandwich enzyme-linked immunosorbent assay (ELISA) was designed to measure the immunologic cross-reactivity and quantity of antigens in target strains of a pathogen. It was first used to measure the factor H-binding protein (fHbp), neisserial adhesin A (NadA), and neisserial heparin-binding antigen (NHBA) content of serogroup B meningococcal (MenB) isolates relative...

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Identifiers

PMID: 22875603
DOI: 10.1128/CVI.00202-12
PMCID: PMC3485892

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