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Article

Phenotyping of tumor biology in patients by multimodality multiparametric imaging: relationship of microcirculation, alphavbeta3 expression, and glucose metabolism.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Nov 2010

Metz Stephan, Ganter Carl, Lorenzen Sylvie, van Marwick Sandra, Herrmann Ken, Lordick Florian, Nekolla Stephan G, Rummeny Ernst J, Wester Hans-Jürgen, Brix Gunnar, Schwaiger Markus, Beer Ambros J

Abstract excerpt

UNLABELLED: Both dynamic contrast-enhanced (DCE) MRI and PET provide quantitative information on tumor biology in living organisms. However, imaging biomarkers often neglect tissue heterogeneity by focusing on distributional summary statistics. We analyzed the spatial relationship of α(v)β(3) expression, glucose metabolism, and perfusion by PET and DCE MRI, focusing on tumor heterogeneity. METHODS: Thirteen...

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Biological Transport
Diagnostic Imaging
Fluorodeoxyglucose F18
Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Integrin alphaVbeta3

Microcirculation

Positron-Emission Tomography

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PMID: 20956471
DOI: 10.2967/jnumed.110.077719

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