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The SR-BI Partner PDZK1 Facilitates Hepatitis C Virus Entry

7 Oct 2010

Abstract excerpt

Entry of hepatitis C virus (HCV) into hepatocytes is a multi-step process that involves a number of different host cell factors. Following initial engagement with glycosaminoglycans and the low-density lipoprotein receptor, it is thought that HCV entry proceeds via interactions with the tetraspanin CD81, scavenger receptor class B type I (SR-BI), and the tight-junction proteins claudin-1 (CLDN1) and occludin...

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PMID: 20949066
DOI: 10.1371/journal.ppat.1001130

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