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A high-throughput cloning system for reverse genetics in Trypanosoma cruzi

13 Oct 2010

Abstract excerpt

BACKGROUND: The three trypanosomatids pathogenic to men, Trypanosoma cruzi, Trypanosoma brucei and Leishmania major, are etiological agents of Chagas disease, African sleeping sickness and cutaneous leishmaniasis, respectively. The complete sequencing of these trypanosomatid genomes represented a breakthrough in the understanding of these organisms. Genome sequencing is a step towards solving the parasite biology...

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PMID: 20942965
DOI: 10.1186/1471-2180-10-259

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