Article
The porcine limbal epithelial stem cell niche as a new model for the study of transplanted tissue-engineered human limbal epithelial cells.
Tissue engineering. Part A - 1 Mar 2011
Notara Maria, Schrader Stefan, Daniels Julie T
Abstract excerpt
Transparency of the human cornea is dependent upon the integrity of its epithelium and hence a population of limbal epithelial stem cells (LESCs). We have previously shown that LESCs reside in limbal epithelial crypts at the periphery of the human cornea. In this study the anatomy and functionality of the porcine limbus was evaluated for the first time as a novel model of the human limbus. Scanning electron...
Topics
- Adhesives
- Animals
- Biomarkers
- Cell Count
- Colony-Forming Units Assay
- Epithelial Cells
- Fluorescent Antibody Technique
- Humans
- Limbus Corneae
- Mice
- Models, Biological
- Phenotype
- Stem Cell Niche
- Stem Cells
- Sus scrofa
- Tissue Engineering
- Wound Healing